Thursday, April 25, 2013

Orders for US durable goods fall 5.7 pct. in March

In this, Wednesday, Feb. 27, 2013, photo, employees load a washer and dryer into customer's car at the loading docks of Nebraska Furniture Mart in Omaha, Neb. The Commerce Department reports on business orders for durable goods in March on Wednesday, April 24, 2013. (AP Photo/Nati Harnik)

In this, Wednesday, Feb. 27, 2013, photo, employees load a washer and dryer into customer's car at the loading docks of Nebraska Furniture Mart in Omaha, Neb. The Commerce Department reports on business orders for durable goods in March on Wednesday, April 24, 2013. (AP Photo/Nati Harnik)

(AP) ? Orders for long-lasting U.S. factory goods fell in March by the most in seven months. The drop reflected a steep decline in commercial aircraft demand and little growth in orders that signal future business investment.

The Commerce Department said Wednesday that orders for durable goods declined 5.7 percent in March. That followed a 4.3 percent gain in February, which was revised lower.

Durable goods are items expected to last at least three years. Orders tend to fluctuate sharply from month to month.

So-called core capital goods, which include industrial machinery and computers, ticked up 0.2 percent. Economists pay close attention to these orders because they strip out more volatile defense and aircraft orders and are a good measure of companies' investment plans.

The March increase in both orders and shipments of core capital goods suggest businesses spent more on equipment and software in the January-March quarter. That likely contributed to economic growth in the first quarter.

Still, most of the gain was from a huge increase in January. Orders fell sharply in February and rose only slightly last month. That indicates businesses may be spending less on equipment in the April-June quarter, economists said.

"There was a clear weakening in orders as the first quarter went on," Paul Ashworth, an economist at Capital Economics, said in a note to clients.

The overall decline in durable goods was exacerbated by a 48.2 percent fall in commercial aircraft orders. Boeing Co. reported that it received orders for only 39 aircraft, compared to 179 in the previous month. Still, even excluding aircraft and transportations demand, orders dropped 1.4 percent, the second straight decline.

Demand fell in most types of goods. Orders dropped for metals such as steel and aluminum, metal parts, electrical equipment and appliances, and defense aircraft. Orders increased for computers and communications equipment.

The economy likely grew at a healthy 3.1 percent annual rate in the first quarter, up from only a 0.4 percent rate in the fourth quarter. The Commerce Department will release its first estimate for January-March growth on Friday.

But many economists expect growth has begun to slow to a rate of 2 percent or less in the current April-June quarter.

One reason is Social Security taxes have reduced Americans' take-home pay this year. That's starting to limit their spending power.

Also, across-the-board government spending cuts that began on March 1 will likely weigh on growth, including manufacturing.

Other reports suggest that manufacturing is starting to weaken after showing signs of strength over the winter. Strong auto production hasn't been enough to offset broader slowdowns in other industries.

Factory output slipped in March, according to a Federal Reserve report last week. And a survey of purchasing managers earlier this month found that manufacturing expanded at a slower pace in March compared with February. The Institute for Supply Management's survey showed that new orders and production declined sharply.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-24-Durable%20Goods/id-11261feae2254873a90852e149edc827

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Nintendo's Miiverse gets mobile access, web interface

Nintendo's Miiverse gets mobile access, web interface

Littered among Nintendo's promises for the year were plans to take Miiverse, the company's social platform, to the next level. That starts today, with the company launching a web portal for the community. Wii U owners can now access their Miiverse activity feed, user menu, notifications and communities through miiverse.nintendo.net using the same login information they created when they first set up their home console. The experience is strictly read-only for now, but can be accessed via mobile or desktop web browser with ease. In addition to being Nintendo's first public foray into the social space, it also marks the first time the company has used its Nintendo Network ID outside of the Wii U ecosystem. According to the company's Twitter account, Nintendo considers this a beta expereince, and has said in the past that a dedicated Miiverse app and 3DS access will be available in the future. For now, Nintendo's social legions will have to settle for a web-based experience -- it may seem like a slow start, but for Nintendo it's a giant leap forward.

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Source: Miiverse, Nintendo (Twitter)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/qOoEAs53bso/

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Wednesday, April 24, 2013

Lawyer: Inspectors clear US horse slaughterhouse - Economy news

ROSWELL, New Mexico (AP) ? The attorney for a proposed horse slaughterhouse in southeastern New Mexico says a federal inspection Tuesday went well and the plant hopes to be in business soon.

Attorney Blair Dunn says agriculture officials found no issues at Valley Meat Co. and told the owners Tuesday they are recommending a grant of inspection be issued immediately. Dunn says he expects final approval for the plant to come in a matter of days.

Valley Meat Co. has become ground zero for an emotional, national debate in America over a return to domestic horse slaughter that has divided horse rescue and animal humane groups, ranchers, politicians and Indian tribes.

Fueling opposition is a recent uproar in Europe over horse meat being found in products labeled as beef. The company hopes the inspection ends a yearlong political drama that has left it idle and made owner Rick De Los Santos and his wife, Sarah, targets of vandalism and death threats.

Valley Meat Co. is a former cattle slaughterhouse whose kill floor has been redesigned for horses to be led in one at a time, secured in a huge metal chute, shot in the head, then processed into meat for shipment overseas.

At issue was whether horses are livestock or pets, and whether it is more humane to slaughter them domestically than to ship tens of thousands of neglected, unwanted and wild horses thousands of miles (kilometers) to be slaughtered in Mexico or Canada.

Front and center of the debate is De Los Santos, who along with his wife, has for more than two decades worked this small slaughterhouse, taking in mostly cows that were too old or sick to travel with larger herds to the bigger slaughterhouses for production.

Now, with cattle herds shrinking amid an ongoing drought, De Los Santos says he and his wife are just trying to transform their business and make enough money to retire by slaughtering domestically some of the thousands of horses that he says travel through the state every month on their way to what are oftentimes less humane and less regulated plants south of the border.

"They are being slaughtered anyway. We thought, well, we will slaughter them here and provide jobs for the economy," De Los Santos said. Instead, Valley Meat has been ensnarled in a yearlong political drama that has left the plant idle and its owners the target of vandalism and death threats ? warnings that increased after humane groups found a video a now-former plant worker posted of himself cursing at animal activists, then shooting one of his own horses to eat.

"People are saying, 'We will slit your throat in your sleep. We hope you die. We hope your kids die,'" De Los Santos said. "Sometimes it's scary. ... And it's all for a horse." Indeed, voice mails left on the company's answering machine spew hate and wishes for violence upon the family.

"I hope you burn in hell," said one irate woman who called repeatedly, saying, "You better pack your (expletive) bags (expletive) and get out of there because that place is finished." The couple have hired security and turned over phone records to federal authorities.

"It's complicated, this industry of feeding the world," Sarah De Los Santos says matter-of-factly. The meat would be processed for human consumption and exported to countries in eastern Europe and Asia.

The Obama administration wants to prohibit horse slaughter. The administration's 2014 budget request excludes money for inspectors for horse slaughter plants, which would effectively keep them from operating.

Humane groups and politicians including Gov. Susana Martinez and New Mexico Attorney General Gary King strongly oppose the plant. They argue that horses are iconic animals in the West, and that other solutions and more funding for horse rescue and birth control programs should be explored over slaughter.

Still others are pushing for a return to domestic slaughter. Proponents include several Native American tribes, the American Quarter Horse Association, some livestock associations and even a few horse rescue groups that believe domestic slaughter would be more humane than shipping the animals elsewhere.

Follow Jeri Clausing at https://twitter.com/jericlausing

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Source: http://www.mail.com/int/business/economy/2039896-lawyer-inspectors-clear-us-horse-slaughterhouse.html

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Atrophy in key region of brain associated with multiple sclerosis

Atrophy in key region of brain associated with multiple sclerosis [ Back to EurekAlert! ] Public release date: 23-Apr-2013
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Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

OAK BROOK, Ill. Magnetic resonance imaging (MRI) measurements of atrophy in an important area of the brain are an accurate predictor of multiple sclerosis (MS), according to a new study published online in the journal Radiology. According to the researchers, these atrophy measurements offer an improvement over current methods for evaluating patients at risk for MS.

MS develops as the body's immune system attacks and damages myelin, the protective layer of fatty tissue that surrounds nerve cells within the brain and spinal cord. Symptoms include visual disturbances, muscle weakness and trouble with coordination and balance. People with severe cases can lose the ability to speak or walk.

Approximately 85 percent of people with MS suffer an initial, short-term neurological episode known as clinically isolated syndrome (CIS). A definitive MS diagnosis is based on a combination of factors, including medical history, neurological exams, development of a second clinical attack and detection of new and enlarging lesions with contrast-enhanced or T2-weighted MRI.

"For some time we've been trying to understand MRI biomarkers that predict MS development from the first onset of the disease," said Robert Zivadinov, M.D., Ph.D., FAAN, from the Buffalo Neuroimaging Analysis Center of the University at Buffalo in Buffalo, N.Y. "In the last couple of years, research has become much more focused on the thalamus."

The thalamus is a structure of gray matter deep within the brain that acts as a kind of relay center for nervous impulses. Recent studies found atrophy of the thalamus in all different MS disease types and detected thalamic volume loss in pediatric MS patients.

"Thalamic atrophy may become a hallmark of how we look at the disease and how we develop drugs to treat it," Dr. Zivadinov said.

For this study, Dr. Zivadinov and colleagues investigated the association between the development of thalamic atrophy and conversion to clinically definite MS.

"One of the most important reasons for the study was to understand which regions of the brain are most predictive of a second clinical attack," he said. "No one has really looked at this over the long term in a clinical trial."

The researchers used contrast-enhanced MRI for initial assessment of 216 CIS patients. They performed follow-up scans at six months, one year and two years. Over two years, 92 of 216 patients, or 42.6 percent, converted to clinically definite MS. Decreases in thalamic volume and increase in lateral ventricle volumes were the only MRI measures independently associated with the development of clinically definite MS.

"First, these results show that atrophy of the thalamus is associated with MS," Dr. Zivadinov said. "Second, they show that thalamic atrophy is a better predictor of clinically definite MS than accumulation of T2-weighted and contrast-enhanced lesions."

The findings suggest that measurement of thalamic atrophy and increase in ventricular size may help identify patients at high risk for conversion to clinically definite MS in future clinical trials involving CIS patients.

"Thalamic atrophy is an ideal MRI biomarker because it's detectable at very early stage," Dr. Zivadinov said. "It has very good predictive value, and you will see it used more and more in the future."

The research team continues to follow the study group, with plans to publish results from the four-year follow-up next summer. They are also trying to learn more about the physiology of the thalamic involvement in MS.

"The next step is to look at where the lesions develop over two years with respect to the location of the atrophy," Dr. Zivadinov said. "Thalamic atrophy cannot be explained entirely by accumulation of lesions; there must be an independent component that leads to loss of thalamus."

MS affects more than 2 million people worldwide, according to the Multiple Sclerosis International Foundation. There is no cure, but early diagnosis and treatment can slow development of the disease.

###

"Thalamic Atrophy is Associated with Development of Clinically Definite Multiple Sclerosis." Collaborating with Dr. Zivadinov were Eva Havrdov, M.D., Ph.D., Niels Bergsland, M.S., Michaela Tyblova, M.D., Jesper Hagemeier, M.S., Zdenek Seidl, M.D., Ph.D., Michael G. Dwyer, M.S., Manuela Vaneckova, M.D., Ph.D., Jan Krasensky, M.Sc., Ellen Carl, Ph.D., Tomas Kalincik, M.D., Ph.D., Dana Horkov, M.D., Ph.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.

RSNA is an association of more than 51,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on MRI, visit RadiologyInfo.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Atrophy in key region of brain associated with multiple sclerosis [ Back to EurekAlert! ] Public release date: 23-Apr-2013
[ | E-mail | Share Share ]

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

OAK BROOK, Ill. Magnetic resonance imaging (MRI) measurements of atrophy in an important area of the brain are an accurate predictor of multiple sclerosis (MS), according to a new study published online in the journal Radiology. According to the researchers, these atrophy measurements offer an improvement over current methods for evaluating patients at risk for MS.

MS develops as the body's immune system attacks and damages myelin, the protective layer of fatty tissue that surrounds nerve cells within the brain and spinal cord. Symptoms include visual disturbances, muscle weakness and trouble with coordination and balance. People with severe cases can lose the ability to speak or walk.

Approximately 85 percent of people with MS suffer an initial, short-term neurological episode known as clinically isolated syndrome (CIS). A definitive MS diagnosis is based on a combination of factors, including medical history, neurological exams, development of a second clinical attack and detection of new and enlarging lesions with contrast-enhanced or T2-weighted MRI.

"For some time we've been trying to understand MRI biomarkers that predict MS development from the first onset of the disease," said Robert Zivadinov, M.D., Ph.D., FAAN, from the Buffalo Neuroimaging Analysis Center of the University at Buffalo in Buffalo, N.Y. "In the last couple of years, research has become much more focused on the thalamus."

The thalamus is a structure of gray matter deep within the brain that acts as a kind of relay center for nervous impulses. Recent studies found atrophy of the thalamus in all different MS disease types and detected thalamic volume loss in pediatric MS patients.

"Thalamic atrophy may become a hallmark of how we look at the disease and how we develop drugs to treat it," Dr. Zivadinov said.

For this study, Dr. Zivadinov and colleagues investigated the association between the development of thalamic atrophy and conversion to clinically definite MS.

"One of the most important reasons for the study was to understand which regions of the brain are most predictive of a second clinical attack," he said. "No one has really looked at this over the long term in a clinical trial."

The researchers used contrast-enhanced MRI for initial assessment of 216 CIS patients. They performed follow-up scans at six months, one year and two years. Over two years, 92 of 216 patients, or 42.6 percent, converted to clinically definite MS. Decreases in thalamic volume and increase in lateral ventricle volumes were the only MRI measures independently associated with the development of clinically definite MS.

"First, these results show that atrophy of the thalamus is associated with MS," Dr. Zivadinov said. "Second, they show that thalamic atrophy is a better predictor of clinically definite MS than accumulation of T2-weighted and contrast-enhanced lesions."

The findings suggest that measurement of thalamic atrophy and increase in ventricular size may help identify patients at high risk for conversion to clinically definite MS in future clinical trials involving CIS patients.

"Thalamic atrophy is an ideal MRI biomarker because it's detectable at very early stage," Dr. Zivadinov said. "It has very good predictive value, and you will see it used more and more in the future."

The research team continues to follow the study group, with plans to publish results from the four-year follow-up next summer. They are also trying to learn more about the physiology of the thalamic involvement in MS.

"The next step is to look at where the lesions develop over two years with respect to the location of the atrophy," Dr. Zivadinov said. "Thalamic atrophy cannot be explained entirely by accumulation of lesions; there must be an independent component that leads to loss of thalamus."

MS affects more than 2 million people worldwide, according to the Multiple Sclerosis International Foundation. There is no cure, but early diagnosis and treatment can slow development of the disease.

###

"Thalamic Atrophy is Associated with Development of Clinically Definite Multiple Sclerosis." Collaborating with Dr. Zivadinov were Eva Havrdov, M.D., Ph.D., Niels Bergsland, M.S., Michaela Tyblova, M.D., Jesper Hagemeier, M.S., Zdenek Seidl, M.D., Ph.D., Michael G. Dwyer, M.S., Manuela Vaneckova, M.D., Ph.D., Jan Krasensky, M.Sc., Ellen Carl, Ph.D., Tomas Kalincik, M.D., Ph.D., Dana Horkov, M.D., Ph.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.

RSNA is an association of more than 51,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on MRI, visit RadiologyInfo.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/rson-aik041613.php

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Groupon Adds Global Search To iPhone, Android, Now Supports Android Tablets To Sharpen Up For Yelp, Foursquare Rivalry

Groupon global searchGroupon’s VP of mobile, David Katz, says that it has been “business as usual” at the daily deals company since the dramatic departure of founder/CEO Andrew Mason. “We’re still just focused on shipping new stuff,” Katz told TechCrunch in an interview. Today, that includes news of updates to Groupon’s iPhone and Android apps: it is adding a universal search feature that will let consumers use the apps to search for Marketplace deals that are available nearby, covering not just local discounts that are time-sensitive but rolling offers that are not. The search feature lays the groundwork for a larger attack that publicly traded Groupon is making on mobile to stay competitive in location-based mobile services against the likes of Google, Yelp and Foursquare — with the latter just raising $41 million to position itself as a platform for local search, offering local deals as an added twist. On top of the new search updates, the Android app is now able to support tablets, the first time that it has been optimized for screens of up to 10 inches. With the search feature available now in the U.S., Groupon plans to turn the feature on across the rest of its mobile footprint this year, Katz says. And while the iPad app is not getting an update today, Groupon says that this week it is extending the number of countries where it will work. Belgium, Japan, Malaysia, South Africa and Switzerland are getting added, taking the total to 18 countries. That’s still a far cry from the 42 that Groupon supports with its iPhone app, but Katz says that they hope to reach parity “by the end of the year, if not sooner.” iOS usage, he says, “still dominates” on Groupon’s platform but the company’s move to roll out features like search internationally, into countries where Android is stronger than iOS, may see that balance changing, which is why it’s important for Groupon to not only keep updating that Android app but add tablet support as well. Groupon’s bid to “transition from being just daily deals into a more complete offering,” in Katz’s words, is so far showing some signs of paying off, with both mobile and non-time-specific Marketplace deals playing roles in that. About half of the company’s local transaction volume in North America is coming from its Deals Marketplace at the moment, and that deal bank (Groupon’s internal term for

Source: http://feedproxy.google.com/~r/Techcrunch/~3/QSKAnOF22Cw/

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Tuesday, April 23, 2013

BMI Songwriter Chris Wallace to Perform at Media Finance Focus ...

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News

April 22, 2013

Photo

BMI is proud to present a performance by acclaimed BMI pop artist Chris Wallace as part of its sponsorship of the Membership Awards Ceremony at Media Finance Focus 2013, the industry?s primary source of professional education for financial and business executives in radio, TV and cable. Wallace, whose breakout hit ?Remember When? was named by iTunes as one of the ?Best Songs Of 2012,?and his debut album, ?Push Rewind,? the ?Best Breakthrough Pop Album Of 2012,?will perform at the BMI-sponsored ?Happy Hour and a Half? on May 22, 2013, marking BMI?s 18th consecutive year as a conference sponsor and its seventh year as host of the Media Financial Management Association?s annual member awards ceremony.

As a teen, Wallace began playing lead guitar in local bar bands before he eventually put together his own band, Quad Four. After posting one of his songs on MySpace, he was signed to Epic Records. He then formed the band White Tie Affair, releasing a hugely successful debut album entitled ?Walk This Way,? and went on to perform with artists from all across the musical spectrum as part of the band?s participation in the Warped Tour, Cyndi Lauper?s True Colors Tour and Lady Gaga?s Fame Ball Tour. In addition to the accolades from iTunes, Wallace?s ?Remember When? has ranked No. 24 on USA TODAY's top 40 airplay chart, while its video has garnered more than 1.6 million YouTube views.

Source: http://www.bmi.com/news/entry/bmi_songwriter_chris_wallace_to_perform_at_media_finance_focus_2013

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Genetic circuit allows both individual freedom, collective good

Apr. 22, 2013 ? Individual freedom and social responsibility may sound like humanistic concepts, but an investigation of the genetic circuitry of bacteria suggests that even the simplest creatures can make difficult choices that strike a balance between selflessness and selfishness.

In a study published online this week in the journal Scientific Reports, researchers from Rice University's Center for Theoretical Biological Physics (CTBP) and colleagues from Tel Aviv University and Harvard Medical School show how sophisticated genetic circuits allow an individual bacterium within a colony to act on its own while also ensuring that the colony pulls together in hard times.

"Our findings suggest new principles for collective decisions that allow both random behavior by individuals and nonrandom outcomes for the population as a whole," said study co-author Eshel Ben-Jacob, a senior investigator at CTBP and adjunct professor of biochemistry and cell biology at Rice. "These new principles could be broadly applicable, from the study of cancer metastasis to the study of collective decisions by humans during times of stress."

Some species of bacteria live in complex colonies that can contain millions of individual cells. An increasing body of research on bacterial colonies has found that members often cooperate -- even to the point of sacrificing their lives -- for the survival of their colony. For example, in response to extreme stress, such as starvation, most of the individual cells in a colony of the bacteria Bacillus subtilis will form spores. Spore formation is a drastic choice because it requires the cell to kill itself to encase a copy of its genetic code in a tough, impervious shell. Though the living cell dies, the spore acts as a kind of time capsule that allows the organism to re-emerge into the world of the living when conditions improve.

"This time-travel strategy of waiting and safeguarding a copy of the DNA in the spore ensures the survival of the colony," Ben-Jacob said. "But there are other, less desperate options that B. subtilis can take to respond to stress. Some of these cells turn into highly mobile food seekers. Others turn cannibalistic, and about 10 percent enter a state called 'competence' in which they bide their time and bet on present conditions to improve."

Scientists have long been curious about how bacteria decide which of these paths to pursue. Years of studies have determined that each individual constantly senses its environment and continuously sends out chemical signals to communicate with its neighbors about the choices it is making. Experimental studies have revealed dozens of regulatory genes, signaling proteins and other genetic tools that cells use to gather information and communicate with one another.

"Bacteria don't hide their intentions from their peers in the colony," said study co-author Jos? Onuchic, co-director of CTBP, Rice's Harry C. and Olga K. Wiess Professor of Physics and Astronomy and professor of chemistry and biochemistry and cell biology. "They don't evade or lie, but rather communicate their intentions by sending chemical messages among themselves."

Individual bacteria weigh their decisions carefully, taking into account the stress they are facing, the situation of their peers, the statistics of how many cells are sporulating and how many are choosing competence, Onuchic said. Each bacterium in the colony communicates via chemical "tweets" and performs a sophisticated decision-making process using a specialized complex gene network composed of many genes connected via complex circuitry. Taking a physics approach, Onuchic, Ben-Jacob and study co-authors Mingyang Lu, Daniel Schultz and Trevor Stavropoulos investigated the interplay between two components of the circuitry -- a timer that determines when sporulation occurs and a two-way switch that causes the cell to choose competence over sporulation.

"We found that the sporulation timer and the competence switch work in a coordinated fashion, but the interplay is complex because the two circuits are affected very differently by noise," said Schultz, a postdoctoral fellow at Harvard Medical School and a former graduate student at CTBP.

Noise results from random fluctuations in a signal; every circuit -- whether genetic or electronic -- responds to noise in its own way. In the case of B. subtilis, noise is undesirable in the sporulation timer but is a necessity for the proper function of the competence switch, the researchers said.

"Our study explains how the two opposite noise requirements can be satisfied in the decision circuitry in B. subtilis," Onuchic said. "The circuits have a special capacity for noise management that allows each individual bacterium to determine its fate by 'playing dice with controlled odds.'"

Ben-Jacob said the timer has an internal clock that is controlled by cell stress. The noise-intolerant timer typically keeps the competence switch closed, but when the cell is exposed to stress over a long period of time, the timer activates a decision gate that opens brief "windows of opportunity" in which the competence switch can be flipped.

Thanks to its architecture, the gate oscillates during the window of opportunity, he said. At each oscillation, the switch opens for a short time and grants the cell a short window in which it can use noise as a "roll of the dice" to decide whether to escape into competence.

"The ingenuity is that at each oscillation the cell also sends 'chemical tweets' to inform the other cells about its stress and attempt to escape," said Ben-Jacob, the Maguy-Glass Professor in Physics of Complex Systems and professor of physics and astronomy at Tel Aviv University. "The tweets sent by others help regulate the circuits of their neighbors and guarantee that no more than a specific fraction of cells within the colony will enter into competence."

Onuchic said the decision-making principles revealed in the study could have implications for synthetic biologists who wish to incorporate sophisticated decision systems as well as for cancer researchers who are interested in exploring the decision-making processes that cancer cells use in choosing to become dormant or to metastasize.

"This represents a real fusion of ideas from statistical physics and biology," he said.

Lu is a postdoctoral research fellow at CTBP and Stavropoulos is a former graduate student and CTBP fellow at the University of California, San Diego. The research was funded by the National Science Foundation, the Cancer Prevention and Research Institute of Texas and the Tauber Family Foundation.

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The above story is reprinted from materials provided by Rice University.

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Journal Reference:

  1. Daniel Schultz, Mingyang Lu, Trevor Stavropoulos, Jose' Onuchic, Eshel Ben-Jacob. Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate. Scientific Reports, 2013; 3 DOI: 10.1038/srep01668

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/gz6J2r-SJZQ/130422123042.htm

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